Background: Genital infections are among the most common diseases for which women refer to gynecologists. VULVOVAGINAL CANDIDIASIS is the second most common infection among women.Objective: A few studies have been conducted on new therapeutic regimens improving the effectiveness of current medications; accordingly, the present study was conducted to compare the effectiveness of clotrimazole with clotrimazole plus probiotics in the treatment of VULVOVAGINAL CANDIDIASIS.Materials and Methods: The present double-blind clinical trial was conducted on 80 women admitted to Shohada hospital in Tehran in 2014. The participants were randomly divided into 2 groups of clotrimazole and clotrimazole plus probiotics. The collected data included the participants’ sociodemographic information and their medical records along with their symptoms and laboratory results before and after the treatment. Finally, the collected data were analyzed using chi-square test, t test, McNemar test and Fisherexact test.Results: The results showed that both treatments (i.e. clotrimazole and clotrimazole plus probiotics) are equally effective in the treatment of VULVOVAGINAL CANDIDIASIS (P=0.499).Conclusion: The results of the present study indicated that supplementing clotrimazole with probiotics results in similar effects compared to administering clotrimazole alone in the treatment of VULVOVAGINAL CANDIDIASIS.

Background: VULVOVAGINAL CANDIDIASIS is a fungal disease with itching, and thick white vaginal discharge. 70-75% of normal healthy adult women report having had at least one episode in their life; Candida albicans is identified as the most common cause. The objective of this study was to identify the different candida species in the vaginal swabs of patients with vulvo-vaginitis.Methods: 175 vaginal swab specimens, from patients admitted in the Gynecology Department of Mahdieh Hospital with recurrent and non-recurrent vulvovaginitis, were cultured on SDA medium. The isolates were subcultured onto CHROM agar Candida medium and incubated at 3TC for 48h.Results: In 89.7% of cases, single candida species"and in 10.3%, multiple candida species were isolated. Frequency of different isolates was as follows: C. albicans (65.1%), C. glabrata (13.1%), C. tropicalis (6.2%), C. krusei (4%), C. guilliermondii (0.6%), C. parapsilosis (0.6%), C. glabrata and C. albicans (5.7%), C. albicans and c.parapsilosis (1.1%), C. glabrata and C. tropicalis (0.6%), C. krusei and C.tropicalis (0.6%), C. albicans and C. tropicalis (0.6%), C. krusei and C. albicans (0.6%), C. glabrata and C. krusei (0.6%), and C. glabrata and C. krusei and C. albicans (0.6%).Conclusion: Our findings suggest that, the common cause of both recurrent and non-recurrent VULVOVAGINAL CANDIDIASIS was C. albicans, followed by C. glabrata.

Background: VULVOVAGINAL CANDIDIASIS (VVC) is an ordinary infection caused by Candida species. Meanwhile, a shift towards nonalbicans Candida (NAC) species has been detected in VVC patients. Objectives: This study aimed at molecular identification of Candida isolates, causing VVC. Methods: Vaginal secretion samples of 320 non-pregnant vaginitis patients at Shahid Akbar-Abadi Obstetrics and Gynecology Hospital in Tehran (Iran) were collected. Samples were evaluated using mycological and molecular approaches. Vaginitis isolates were analyzed with thePCRusing NL1andNL4primers, andthe D1/D2 region of the large-subunitrRNAgenewasamplifiedandsequenced. Results: In total, 100 Candida isolates were identified from VVC and recurrent VULVOVAGINAL CANDIDIASIS (RVVC). Candida albicans was the most frequent (51%), followed by C. glabrata (36%), C. krusei (Pichia kudriavzevii) (8%), and C. kefyr (Kluyveromyces marxianus) (5%). 51 and 49% of isolates had C. albicans and NAC, respectively. Conclusions: Candida albicans and C. glabrata were the mostcommonagents of VULVOVAGINAL CANDIDIASIS. NACspp. (49%) was found as an important agent associated with VVC.